They had the entire offseason to prepare for their tempo, so I'd say Sparty has a good shot, but I'll take Mariota over Cook.
Oregon hasn't faced a Big Ten defense like that. Big Ten defenses don't mess around. Oregon 56 MSU 10
Oregon's offense isn't unstoppable. It's just they really make you pay for any mistakes. Solid, physical defenses can hold them down. I don't know if MSU wins but they have the kind of defense that should keep them in the game.