Remember if aspects of the game seem too hard, tweak the sliders. Cheap, but at least then you might be able to enjoy it.
Also, Tay Mart is sick. Id definitely recommend using him as your QB. His 96 acceleration is probably tops on the team, but don't quote me on it, a receiver/DB might have him beat. Still, that is ridiculous for a QB. Scrambling is quite easy if your opponent doesn't know how to click onto nearby defender as you sprint past them.
Also, I just won my second online game, and fooled around by putting Eric Hagg in for Sean Fisher at OLB. Definitely let's you get more speed on the field. And his out of position 77 overall is two above Fish's 75... sorry Fish!