Specifically during the KU game, every long pass to Niles Paul was a jump-ball. If Niles has the guy by 3 yards, he has to check-up, stop and jump to get that ball. Not necessarily a high-percentage catch (although Niles made it look easily), and with a Safety coming over, a good defender will make that receiver pay by knocking his legs out from under him or blasting him out of bounds. On the other hand, if you place the ball down the field near the sideline, if you overthrow, you just get an incompletion, but you avoid the interception or the risk of getting your receiver torn apart.
I give TO all the respect in the world, but the pass definitely wasn't his bread and butter. If I want advice on the option or smash-mouth football, TO is your man. If you want advice on pocket or play-action passing, you probably want to look elsewhere.