We should punish teams who try that by scheming an RPO off of a zone read look.
Have a TE lined up as an H-back just behind the LOS opposite of the RB; this will cause the defense to shift their LBs to the strong side. You could also have the TE lined up next to the RT, for a more traditional look.
Have two wideouts split out on the backside of the play, and a third split out on the strong side.
Snap the ball, leave the backside DE (or LB, if they are in 3-4) unblocked; if DE stays home, hand it off. If he crashes towards the RB, pull the ball and run.
Next, read the Will LB (or backside ILB in 3-4); if he drops into a 'flat zone' coverage, cut inside and run the ball. If he flows towards the QB, pass to the bubble route.
At the snap, the farthest WR on the backside runs a bubble route towards the inside, while the nearest WR steps up as if he would be blocking the CB or S covering him. Instead of blocking, though, he slips past and has space behind the coverage.
If the CB/nickel back/Free Safety drops into coverage, hit the bubble for a good 5-10 yards: this is the most likely scenario if they are playing a soft coverage.
If the CB bites hard on the bubble (the 'traditional' target of an RPO), pass to the streaking receiver behind him.
The QB makes three reads in this play; DE (or OLB in 3-4) Will LB, and FS or nickel back. This play attacks the 'backside' of a formation after forcing the defense to shade towards the strong side of the line. It would work better if the inside zone or strong-side outside zone run game was working well, and would punish aggressive defenses, especially ones that are dedicated to stopping Martinez's runs. They read run, crash down towards the line, and the ball gets thrown over their heads.
Technically, there are four options, but all three reads are in the same direction from the QBs point of view, so the three reads shouldn't be difficult for a college QB to manage, especially one that is already used to zone reads and RPOs.